Life

Metformin is a bedrock of modern medicine and the first-line treatment for most people with diabetes. Excitement about its potential as an anti-aging drug grew after early observational studies suggested surprising longevity benefits, but more rigorous follow-up research pulled us back closer to square one. Newer studies suggest that while metformin improves glucose metrics, it may also impair adaptations to aerobic and strength training, among the most powerful interventions for extending healthspan and lifespan. The result is a messier, more nuanced picture that demands personalized care rather than broad preventive use.